Laboratory HME Hot Melt Extruder

Hot melt extrusion process, the API and the carrier as well as a variety of complementary makings after joining extruder, the extruding machine, under the action of mechanical force and barrel plus heat, first of all, the material melt, then distribution and dispersive mixing make API and various auxiliary materials evenly dispersed in carrier, removing wave action will further degradation of small molecules and moisture removal from the material, Finally, the material is extruded from the head by the extruder screw. After the material is extruded from the extruder, it can be cooled and shaped by air cooling, water cooling and cooling rolls, etc. Finally, it can be crushed, granulated or rerolled according to the needs of the agent, as shown in picture

Video of  Laboratory HME Hot Melt Extruder

 Applications of Laboratory HME Hot Melt Extruder

Laboratory HME Hot Melt Extruder is mainly used in the following aspects:

1) To improve the solubility and bioavailability of drugs

2) Preparation of slow-controlled or delayed release preparations

3) Prepare localized release preparations

4) Non-gastrointestinal storage and local drug delivery systems

5) Masking the API's bad taste

Hot melt extrusion technology has been widely used in foreign countries, and a number of drugs have been approved by FDA, as shown in the following table. In addition, hot melt extrusion technology has been used in China.

The prepared drug was marketed.

Screw extrusion process of Laboratory HME Hot Melt Extruder

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